Kidney phosphate wasting can be due to genetic (e.g. X-Linked Hypophosphatemia) or acquired causes ( Iron infusion, Fanconi syndrome, oncogenic osteomalacia).
Hypophosphataemia leads to osteomalacia/ rickets, myopathy, and skeletal fragility.
Kidney phosphate wasting is diagnosed using the TmP/GFR, the ratio of the maximum rate of tubular phosphate reabsorption to the glomerular filtration rate.
This requires a paired collection of blood and a second void fasting urine sample.
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