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Final Scientific Program
Below is the final program for the ASM, Wed 7th
to Fri 9th Sept.
SEE ALSO:
- Satellite Meeting
program for Tues 6th Sept
- Social Events for Wed
and Thur evenings.
NOTE ON PRINTING:
Use the 'print' button (above-right) to open a printer
friendly version of the program. See also, note
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| Wednesday,
7 September 2005 |
| 07:45 |
Coach to Perth Convention
Centre (from Burswood lobby) |
| 08:30 |
ESA PLENARY SESSION
Chair - Mark McLean
New roles for old hormones and the Gordian knot
of human birth
Roger Smith |
| 09:30 |
Morning Tea |
| |
ANZBMS
/ ESA BONE SYMPOSIUM:
Osteoporosis therapeutic
update
Sponsored by Merck Sharp & Dohme
Chairs - Ego Seeman & Jeffrey
Zajac |
| 10:00 |
Mechanisms of action
of current and emerging therapies
Prof. Jack Martin |
| 10:30 |
Calcium supplementation
and/or vitamin D in osteoporosis – myth
or reality?
A/Prof. Richard Prince |
| 11:00 |
Sex hormone replacement
and SERMs
Prof. John Eisman |
| 11:30 |
Osteoporosis: Whom to
treat? What drug?
Prof. Richard Eastell |
| 12:15 |
Coach to Burswood |
| 12:30 |
Lunch and trade displays |
| 13:00 |
INDUSTRY SYMPOSIUM
Sponsored by Servier Laboratories
Chair – Jack Martin
Protos: a new way to treat post-menopausal osteoporosis
Prof. Ego Seeman, Prof. John
Eisman & Prof. Philip Sambrook |
| |
WHAT’S
NEW IN THE PARATHYROID?
Chairs – Philip Sambrook & Ian
Reid |
| 14:30 |
Genetics of parathyroid
gland development and hypoparathyroidism
Prof. Rajesh Thakker |
| 15:00 |
Hyperparathyroidism
and parathyroid carcinoma – insights from
gene profiling
Dr. Deborah Marsh |
| 15:30 |
The changing face of
parathyroid surgery
Prof. Leigh Delbridge |
| 16:00 |
Afternoon Tea |
| |
APPROACHES
TO PROBLEMS OF SKELETAL INTEGRITY
Chairs - Jill Cornish & Kong
Wah Ng |
| 16:30 |
Therapeutic approaches
to metastatic bone disease
Prof. Brendan Boyce |
| 17:00 |
Targeting of bone cancer
with Apo2L/TRAIL
Dr. Andreas Evdokiou |
| 17:30 |
Prospective isolation
of mesenchymal stem cells in man and mouse
Prof. Paul Simmons |
| 18:00 |
Posters and Welcome Reception
Exhibition Area |
^ top
| Thursday, 8
September 2005 |
| 07:00 |
Merck Sharp & Dohme Fun Run |
| |
CALCIUM
SENSING RECEPTOR
Chairs – Matthew Brown & Tom
Ratajczak |
| 08:30 |
The calcium sensing receptor
and its seven
clinical disorders
Prof. Rajesh Thakker |
| 09:10 |
Clinical implications
of the calcium receptor’s multiple sensing
domains
A/Prof. Arthur Conigrave |
| |
FREE ORALS: |
| 09:40 |
High bone turnover predicts
mortality in the frail elderly: a prospective
cohort study
Markus Seibel, PN
Sambrook, C Chen, L March, I Cameron, R Cumming & J
Simpson |
| 09:50 |
IL-11 and IL-6 stimulation
of osteoclast formation depends on STAT but not
ERK-mediated pathways in osteoblasts
Julian Quinn, A
Nakamura, BJ Jenkins, NA Sims, M Ernst, TJ Martin & MT
Gillespie |
| 10:00 |
AC45, a V-ATPase accessory
subunit interacts with VO domain subunits and
is necessary for osteoclastic bone resorption
Taksum Cheng, H
Feng, KHM Yip, A Carrello, R Seeber, KM Kroeger,
K Eidne, MH Zheng & J Xu |
| 10:10 |
Calcium supplement for
improving bone mineral density in children: systematic
review
Tania Winzenberg,
K Shaw, J Fryer & G Jones |
| 10:20 |
Global knock-down of
the calcitonin receptor (CTR) in young female
mice results in decreased trabecular bone volume
Rachel Davey, JF
McManus, AJ Moore, WSM Chiu, AM Axell, AJ Notini,
HA Morris, DM Findlay & JD Zajac |
| 10:30 |
Morning Tea |
| |
YOUNG
INVESTIGATOR AWARD PRESENTATIONS
Chairs - Jack Martin & Roger
Price |
| 11:00 |
Differential activity
of human RUNX2 P2 promoter alleles associated
with an allele-specific DNA-protein interaction
James Doecke, CJ Day, AJ
Stephens, G Nicholson & N
Morrison |
| 11:15 |
MCP-1 induces super abundant
NFATC1 expression and results in TRAP+ multinuclear
cells with calcitonin receptor expression, but
these fail to resorb bone and are not osteoclasts
Michael Kim, CJ Day, CL Magno,
SRJ Stephens & NA
Morrison |
| 11:30 |
Remaining lifetime risk
of fractures in elderly men and women
Nguyen Nguyen Dinh, H Alhborg,
JR Center, JA Eisman & TV Nguyen |
| 11:45 |
Paget's disease in people
inheriting mutations in the P62 gene
Mark Bolland, K Callon, D
Naot, PC Tong, D Wattie & T
Cundy |
| 12:00 |
Glutamine repeat mutations
define a new CBFA1/RUNX2 related syndrome with
decreased femoral neck BMD, decreased calcaneal
broadband ultrasound and increased risk of osteoporotic
fracture
Alex Stephens, JD Doecke,
SH Ralston, RL Prince, GC Nicholson & NA
Morrison |
| 12:15 |
Variations in the mode
of loading along the bone influences its architecture
rather than the
amount of its mineralised mass
Roger Zebaze, A Jones, M Knackstedt & E Seeman |
| 12:30 |
Targeted silencing of
cathepsin K with siRNA in primary human osteoclast
cells
Tina Selinger, CJ Day & NA
Morrison |
| 12:45 |
Lunch and trade displays |
| 13:00 |
INDUSTRY SYMPOSIUM
Sponsored by Sanofi Aventis
The role of bone strength in osteoporosis
Prof. Philip Sambrook
Surrogate markers: how much do they really
tell us about fracture risk reduction?
Prof. Richard Eastell
|
| |
CONCURRENT SESSION - 14:30
to 16:00
1: Clinical Free Orals & Keynote Presentation |
| |
CLINICAL
FREE ORALS
Chairs - Peter Nash & Jacqueline
Center |
| 14:30 |
Pamidronate therapy for
one year after allogeneic stem cell transplantation
(AlloSCT) reduces bone loss from the lumbar spine,
femoral neck and total hip
Peter Ebeling, P Shuttleworth,
J Reynolds, J Szer, AP Schwarer, AW Roberts,
KF Bradstock, C-H Hui, R Herrmann & AC
Grigg |
| 14:40 |
Zoledronic acid in children:
effect on growth, bone development and bone and
mineral metabolism
Craig Munns, JYH Hong,
J Briody, M McQuade, DG Little & CT
Cowell |
| 14:50 |
Clinical outcomes, risk
of new incident vertebral fractures and survival
of patients presenting with acute osteoporotic
vertebral fractures: percutaneous vertebroplasty
is superior to conservative therapy
Terry Diamond, C Bryant,
L Browne & WA Clark |
| 15:00 |
Hormone therapy use after
the release of principal results from the WHI
trial
Sam Korn, JA Pasco,
MJ Henry, GC Nicholson & MA Kotowicz |
| 15:10 |
Calcium malabsorption
does not increase serum parathyroid hormone in
postmenopausal women
Allan Need, M Horowitz,
P O’Loughlin, P Coates & C Nordin |
| 15:20 |
Calcium-vitamin D3 fortified
milk reduces bone loss in middle aged and older
men: a 2-year randomised controlled trial
Robin Daly, M Brown,
S Bass, S Kukuljan & C Nowson |
| 15:30 |
KEYNOTE PRESENTATION
Chondrocalcinosis and ankylosing spondylitis – two sides of the pyrophosphatase
coin
Prof. Matthew Brown |
| |
CONCURRENT SESSION - 14:30
to 16:00
2: Basic Free Orals & Keynote Presentation |
| |
BASIC
FREE ORALS
Chairs – Rebecca Mason & Gerald
Atkin |
| 14:30 |
Adult deletion of hypothalamic
Y2 receptors improves bone mass following gonadectomy
in mice
Susan Allison, PA Baldock,
A Sainsbury, RF Enriquez, M During, JA
Eisman, H Herzog & EM Gardiner |
| 14:40 |
Central regulation of
cortical bone mass and osteoblast activity by
Y2 receptors: comparison to leptin pathway
Paul Baldock, S Allison,
A Sainsbury, RF Enriquez, H Herzog, EM
Gardiner & JA Eisman |
| 14:50 |
Inhibition of glucocorticoid
signaling by overexpression of 11beta HSD2 in
mature osteoblasts inhibits nodule formation
and increases adipogenesis in vitro
Hong Zhou, K Brennan,
Y Zheng, CR Dunstan & MJ Seibel |
| 15:00 |
Osteoblast targeted overexpression
of hydroxysteroid dehydrogenase type 2 induces
delayed calvarial development in transgenic mice
Colin Dunstan, H Zhou,
K Brennan, Y Zheng & MJ Seibel |
| 15:10 |
Differential activation
of intracellular Ca2+ mobilization and ERK1/2
phosphorylation by the extracellular Ca2+-sensing
receptor stimulated by Ca2+ ions or L-amino acids
Hee-Chang Mun, HJ Lee,
NC Lewis, EL Culverston, RS Mason & AD
Conigrave |
| 15:20 |
Mutational analysis of
exoloop-3 residues of the calcium-sensing receptor
points to a constraining effect of core residues
on wild-type calcium-sensing receptor activation
Bryan Ward, AJ Rea, AL Magno & T Ratajczak |
| 15:30 |
KEYNOTE PRESENTATION
Regulating pathways subserving osteoblast function
A/Prof. Jill Cornish |
| |
CONCURRENT SESSION - 16:30
to 17:30
1: Clinical Free Orals |
| |
CLINICAL
FREE ORALS
Chairs - Nicholas Pocock & Peter
Ebeling |
| 16:30 |
Maternal vitamin D status
and offspring birth size: a prospective study
John Wark,
R Morley,
J Carlin & J Pasco |
| 16:40 |
Factors associated with
skeletal age deviation in children
Graeme Jones, M Gutteridge & D
Ma |
| 16:50 |
A comparison of BMD and
demographic data for predicting clinical fractures
over 5 years
Ian Dick, A Devine & RL
Prince |
| 17:00 |
Genetic effects on bone
loss in peri and post menopausal women: a longitudinal
twin study
Joanna Makovey, V Naganathan,
TV Nguyen & P Sambrook |
| 17:10 |
Genetics and remaining
lifetime risk of fracture: the collagen I alpha
1 gene
Tuan Nguyen, ND Nguyen,
JR Center & JA Eisman |
| 17:20 |
Estimating the prevalence
of coeliac disease in osteodeficient patients
Louise Wienholt, MJ
Hooper, AM Kean, A Conigrave, R Loblay & AJ
William |
| |
CONCURRENT SESSION - 16:30
to 17:30
2: Basic Free Orals |
| |
BASIC
FREE ORALS
Chairs – David Findlay & Geoff
Nicholson |
| 16:30 |
Osteoclast formation
is strongly reduced in the absence of CD47/SIRPα-interaction
Pernilla Lundberg,
C Koskinen, H Löthgren, Å Stenberg,
UH Lerner & P-A Oldenborg |
| 16:40 |
Cardiotrophin-1 regulates
osteoclast formation and function in a manner
distinct from other gp130 cytokines
Natalie Sims, JMW Quinn,
H Saleh & TJ Martin |
| 16:50 |
Scaffold protein p62
modulates osteoclastogenesis through the regulation
of RANKL signaling cascades and TRAF6 in the
ubiquitin-mediated proteasomal pathways
Kirk Yip, MH Zheng & J
Xu |
| 17:00 |
Thioredoxin binding protein-2
is a key inhibitor of osteoclastic bone resorption
Jason Hodge, GC Nicholson & CJ
Aitken |
| 17:10 |
Human osteoclast differentiation
and function are stimulated by exogenous ROS
and RANKL- induced intracellular ROS production
Lauren Hodgson, CJ
Aitken, JM Hodge, MA Chacksfield & GC
Nicholson |
| 17:20 |
Caffeic acid phenethyl
ester, a natural component of honeybee propolis
induces osteoclast apoptosis and attenuates osteoclastogenesis
via the suppression of RANKL-induced NF-kB and
NFAT activity
Jiake Xu, LY Chai,
ESM Ang, N Pavlos, KHM Yip, JH Steer, DA
Joyce & MH Zheng |
| 17:30 |
Annual General Meeting & Awards |
| 19:30 |
Gala Dinner
Grand Ballroom 1, Burswood |
^ top
| Friday, 9 September
2005 |
| |
OSTEOCLAST BIOLOGY AND
PAGET’S DISEASE
Chairs - Kay Ibbertson & Matthew Gillespie |
| 09:00 |
Cytokine regulation of
osteoclast formation through NF-kB, c-Fos and
NFATs
Prof. Brendan Boyce |
| 09:45 |
Paget’s disease – genes,
hyperparathyroidism, bisphosphonates, BMD and
fracture responses
Prof. Don Gutteridge |
| 10:15 |
Morning Tea |
| |
CONCURRENT SESSION - 10:45
to 12:15
1: Clinical Free Orals & Keynote Presentation |
| |
CLINICAL
FREE ORALS
Chairs - Tuan Nguyen & John
Wark |
| 10:45 |
A novel mutation (K378X)
in the sequestosome 1 gene: association with
a severe Pagets disease
of bone phenotype and functional implications
of NF-kB activation
Sarah Morgan, L Ward, BK
Ward, J Walsh, J Xu, B Stuckey, N Kent & T
Ratajczak |
| 10:55 |
High IGFBP-2 levels are
associated with an increased risk of osteoporotic
fractures in elderly men
Jacqueline Center, MJ Seibel,
TV Nguyen, C Meier & JA Eisman |
| 11:05 |
Estradiol predicts 5
year fracture risk and forearm cortical density,
volume and strength
Amanda Devine, RL Prince,
SS Dhaliwal & IM Dick |
| 11:15 |
Having a non-melanoma
skin cancer decreases the risk of subsequent
fracture: a record
linkage study
Graeme Jones, V Srikanth,
J Fryer, L Blizzard, A Venn, L Newman, H Cooley & T
Albion |
| 11:25 |
Older women with higher
levels of physical activity and dietary calcium
intake have stronger bones
Michelle Nurzenski, NK Briffa,
RI Price, B Khoo, A Devine, TJ Beck & RL
Prince |
| 11:35 |
Non-invasive, nonionizing
discriminators of prevalent vertebral fracture
cases: a QUS-based model
BK Tan, RI Price, S Song,
SS Dhaliwal & KP Singer |
| 11:45 |
KEYNOTE PRESENTATION
The burden of fracture
Dr. Julie Pasco |
| |
CONCURRENT SESSION - 10:45
to 12:15
2: Basic Free Orals & Keynote Presentation |
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BASIC
FREE ORALS
Chairs – Nigel Morrison & Edith
Gardiner |
| 10:45 |
Evidence for LRP1-independent
actions of lactoferrin in osteoblasts
Qing Zhu, J Cornish, M Watson,
K Callon, IR Reid & A Grey |
| 10:55 |
Dickkopf's are expressed
by breast cancer cell lines and regulated by
PTHrP
Karl Hausler, M Ciccomancini,
N Ilievski, TJ Martin & M Gillespie |
| 11:05 |
Cyclooxygenase-2 mediates
thrombin's inhibition of osteoblast apoptosis
by a Par-1-
independent mechanism
Lay Hoon Loh, CN Pagel, S
Merlin, E Tudor, RN Pike & EJ Mackie |
| 11:15 |
Anabolic and catabolic
bone defects in a mouse model of type 1 neurofibromatosis
(NF1)
Aaron Schindeler & DG
Little |
| 11:25 |
PTHrP sensitises breast
cancer cells to Apo2L/TRAIL-mediated cell death
Steve Bouralexis, TJ Martin & MT
Gillespie |
| 11:35 |
Zoledronic acid treatment
enhances hard callus formation without delaying
endochondral
repair in a rat fracture
M McDonald, Craig Godfrey,
S Dulai & DG Little |
| 11:45 |
KEYNOTE PRESENTATION
Intracellular vesicle transport is required for bone resorption
Dr. Nathan Pavlos |
| 12:15 |
Concluding remarks
A/Prof. Jill Cornish |
| 12:30 |
Close of Meeting |
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